Effect of Acid, Base, Temperature and U.V Light on Amlodipine Besylate

Aim of the present study is to study the stability of Amlodipine besylate in acidic and basic pH, heat and under UV light. Literature survey reveals that various stability studies conducted to prepare stable dosage form and effect of temperature i.e. room temperature and refrigerator. Therefore we took Amlodipine besylate 10mg tablets and by making its dilution 25ug/ml we exposed it to acidic and basic condition, heat and u.v light and noted their absorbance at wavelength 237nm.It is found that Amlodipine absorbance decreases in all the above mentioned stress conditions. It is concluded that stability of Amlodipine besylate decreases in acidic and medium. Stability also decreases in heat and u.v sensitive.